Karsus is a province of the Lady's Empire located along (or at least near) the northern shore of the southern continent, presumably bordering the Sea of Torments. It is far to the east of Beryl, the most ancient of the Jewel Cities. The province is mentioned just once, in The Silver Spike, where it is described as having:

outposts of the empire where auxiliaries recruited from the Orain tribes guarded the frontier against the depredations of their own kind more ferociously and faithfully than did the imperial legions.

Karsus is the ninth specified location in the long, overland odyssey traveled by the demon called Toadkiller Dog, who was following the trail of his new enemy, the Limper. Toadkiller Dog passed through Karsus only after swimming the River Bigotes and the Hyclades, and traversing the Rani Poor desert, the burial mounds of Barbara, the forgotten highways of Laba Larada, the ruins of Khun, the pyramids overlooking the Canyons of the Undead, and the ruins of the temple city of Marsha the Devastator. He then continued eastward, crossing, in order: the Plain of Dano-Patha; the Mountains of Sinjian; and finally, the Straits of Angine and onward into the northern continent, to the Tower at Charm.

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